重磅免疫检查点CTLA-4 (E2V1Z) Rabbit mAb上市 | CST 12月新品上市
Dec. 2021
热门新产品
CTLA-4 (E2V1Z) Rabbit mAb #53560
| 货号 | 规格 | 2021 年目录价 |
|
53560T |
20 µl |
￥1,400.00 |
| 53560S | 100 µl | ￥3,850.00 |
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893
| 货号 | 规格 | 2021 年目录价 |
|
26893SF |
100 µg |
￥7,400.00 |
细胞毒性 T 淋巴细胞蛋白 4 (CTLA-4, CD152) 是 Ig 超家族的一员，能够负向调控 T 细胞的早期激活 (1-4)。CTLA-4 蛋白主要在 T 细胞中表达，包括 CD8+ 细胞毒性 T 细胞、CD4+ 辅助 T 细胞和 CD4+/FoxP3+ 调节性 T 细胞（1,2）。CTLA-4 蛋白与 CD28 在细胞表面争相结合 B7.1 (CD80) 和 B7.2 (CD86)，导致 T 细胞活性下调 (5)。CTLA-4 下游 SHP-2 和 PP2A 的激活会减弱 TCR 信号转导 (6)。研究表明，CTLA4 敲除小鼠患有引起过早死亡的淋巴组织增殖性疾病，表明 CTLA-4 可负向调控 T 细胞 (7)。相应 CTLA4 基因突变与多种疾病有关，包括胰岛素依赖性糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮和 V 型自身免疫性淋巴细胞增殖性综合征 (8,9)。其他研究表明，CTLA-4 阻滞是肿瘤免疫治疗的有效策略 (10-12)。
CST CTLA-4 (E2V1Z) Rabbit mAb #53560 的重要性：CTLA-4 是免疫治疗领域一个非常重要的转化医学相关靶点。研究人员需要观察肿瘤组织微环境中该靶标的表达情况，以识别肿瘤微环境当中免疫细胞的表型和功能。CST CTLA-4 抗体（#53560）是目前市面上两款用于 IHC-P应用的科研抗体之一，在十多种癌症组织样本当中进行了严格的验证 （滑动查看下方验证数据），适用于手动和基于自动染色机的免疫组化实验，是性价比之选。
同时，无载体配方CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893 也可以满足包括质谱流式，成像质谱流式等各种需要特殊抗体偶联的需求，是助力研究人员深入了解肿瘤免疫以及肿瘤微环境并开展转化医学研究的不二选择。
12月新品列表
|
产品货号 |
产品名称 |
实验应用 |
反应性 |
| Adhesion / ECM | |||
| 63034S |
COL3A1 (E8D7R) XP® Rabbit mAb |
WB, IHC-P |
H |
|
MUC5B (E4Y5Z) Rabbit mAb |
IHC-P, IF-IC |
H |
|
|
MUC13 (E6Z1K) Rabbit mAb |
WB, IP, IHC-P, IF-IC |
H |
|
|
PAI-1 (E3I5H) XP® Rabbit mAb |
WB, IHC-P |
H |
|
|
Periostin (E5F2S) Rabbit mAb |
WB, IP, IHC-P |
H |
|
|
Apoptosis |
|||
| 40618S | Gasdermin E Antibody | WB | M, R |
| 88169S | Mcl-1 (D2W9E) Rabbit mAb (Alexa Fluor® 594 Conjugate) | IF-IC, F | H, M, R |
| 66026S | PARP (46D11) Rabbit mAb (Alexa Fluor® 488 Conjugate) | F | H, M, R, Mk |
| 53727S | PARP (46D11) Rabbit mAb (Alexa Fluor® 594 Conjugate) | F | H, M, R, Mk |
| 34366S | PARP (46D11) Rabbit mAb (Alexa Fluor® 647 Conjugate) | F | H, M, R, Mk |
| 58274S | Phospho-RIP (Ser320) Antibody | WB | H |
|
Autophagy |
|||
|
CCPG1 (E3C5G) Rabbit mAb |
WB, IP |
H |
|
| 12074S | Phospho-SQSTM1/p62 (Ser349) (E7M1A) Rabbit mAb (Alexa Fluor® 488 Conjugate) | IF-IC, F | H, M, (R) |
|
Ca, cAMP and Lipid Signaling |
|||
|
PhosphoPlus® PLCγ2 (Tyr759) Antibody Duet |
- |
- |
|
|
Cell Cycle / Checkpoint Control |
|||
|
Phospho-Rb (Ser807) Antibody |
WB |
H |
|
|
XRCC1 (E4A3V) XP® Rabbit mAb |
WB, IP, IHC-P, IF-IC |
H, M, R |
|
|
Chromatin Regulation / Nuclear Function |
|||
| FTSJ3 (E6T9J) Rabbit mAb | WB | H, M | |
|
Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor® 555 Conjugate) |
F |
H, M, R, Mk, (X, Z) |
|
|
Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor® 594 Conjugate) |
F |
H, M, R, Mk, (X, Z) |
|
| 88197C | FastScan™ LbCpf1 (Strain ND2006) ELISA Kit | ELISA | - |
|
MLL1 (E9W9Z) Rabbit mAb (Carboxy-terminal Antigen) |
WB, IP, ChIP |
H, Mk |
|
|
TIF1α/TRIM24 (E9T3N) Rabbit mAb |
WB, IP, IHC-P |
H, M, R, Mk |
|
|
TTF-I Antibody |
WB |
H, M, R, Mk |
|
|
Cytoskeletal Signaling |
|||
| 47610S | KIF5B (E3H4J) Rabbit mAb | WB, IF-IC | H, M, R |
| 62696S | KIF5B (E4A5A) Rabbit mAb | WB, IP, IF-IC | H |
| 47293S | SETD3 Antibody | WB, IP | H, Mk |
| 37430S | ZNF185 (E6W4I) Rabbit mAb | WB, IP, IF-IC | H |
| 86942S | ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor® 488 Conjugate) | IF-IC | H, Mk |
| 98225S | ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor® 647 Conjugate) | IF-IC | H, Mk |
|
Developmental Biology |
|||
|
CD15/SSEA1 (MC480) Mouse mAb (Alexa Fluor® 488 Conjugate) |
IF-IC, F |
M |
|
|
ETV5 (E5G9V) Rabbit mAb |
WB, IP |
H, M |
|
|
Human FGF-9 Recombinant Protein |
- |
- |
|
|
Mouse FGF-9 Recombinant Protein |
- |
- |
|
|
HIF-1α (D1S7W) XP® Rabbit mAb (Biotinylated) |
WB |
H, M, Mk |
|
|
Notch2 (D76A6) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) |
IF-IC, F |
H, M, R |
|
|
POU2F3 (E5N2D) XP® Rabbit mAb |
WB, IHC-Bond, IHC-P |
H |
|
|
RUNX3/AML2 (E8D5W) XP® Rabbit mAb |
WB, IP, IHC-P |
H |
|
|
Human TGF-α Recombinant Protein |
- |
- |
|
|
YAP/TAZ (D24E4) Rabbit mAb (Alexa Fluor® 647 Conjugate) |
F |
H, M, Mk |
|
|
Glucose / Energy Metabolism |
|||
| 66933S | GPAT4 Antibody | WB | H |
|
Immunology and Inflammation |
|||
| 81123S | ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor® 555 Conjugate) | F | M |
| 29956S | ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor® 594 Conjugate) | F | M |
| 90776S | Bcl-3 (E2M6N) Rabbit mAb | WB, F | H |
| 16611S | Bcl-3 (E4D4K) Rabbit mAb | WB, IP, IHC-P | H, M |
| 64137S | Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (Alexa Fluor® 647 Conjugate) | F | H |
| 16803S | Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (PE Conjugate) | F | H |
| 88083S | CD3ζ Antibody | WB | H, M |
| 23578S | CD27 Antibody | WB | M |
| 26233S | CD34 (E2J1K) Rabbit mAb | WB, IF-F, IF-IC | M |
| 46894S | CD37 (E4K2M) Rabbit mAb | WB, IP, F | H |
| 55084S | CD74 (D5N3I) XP® Rabbit mAb (PE Conjugate) | F | H |
| 89660S | Phospho-CD79A (Tyr210) (E8E9Z) Rabbit mAb | WB, F | H |
| 57950S | CLEC12A/CLL-1 (E5T5V) Rabbit mAb | WB, IP, F | H |
|
CTLA-4 (E2V1Z) Rabbit mAb |
WB, IP, IHC-Bond, IHC-P |
H, M |
|
|
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) |
WB, IHC |
H, M |
|
| 87223S | DPEP-1/MDP (E4O6J) XP® Rabbit mAb | WB, IHC-P, IF-IC | H |
| 76290S | DPEP-1/MDP (E5C2V) Rabbit mAb | WB, IF-IC | H |
| 78401S | FcRγ (E6Y1A) Rabbit mAb | WB, IP, IHC-Bond, IHC-P, IF-F, IF-IC | H, M |
| 20085S | FcRn (E4D5I) Rabbit mAb | WB, IHC-P | M, R |
| 45850S | Fibrinogen gamma chain (E1U3Z) XP® Rabbit mAb | WB, IHC-Bond, IHC-P | H |
| 89572S | Galectin-3/LGALS3 (E7B6R) Rabbit mAb | WB, IP, IHC-P, IF-F, IF-IC | H, M, R |
| 99695S | Granzyme H (E3H7W) Rabbit mAb | WB, F | H |
| 61606S | HPK1 (E1C3L) Rabbit mAb (Biotinylated) | WB | H |
| 18526S | IL-2Rγ (E2Z5W) Rabbit mAb | WB, IP, F | M |
| 57529S | Human IL-11 Recombinant Protein | - | - |
| 76561S | Mouse IL-11 Recombinant Protein | - | - |
| 68350S | Integrin α11 Antibody | WB, IP | H |
| 98344S | IRF-8 (E8X4K) Rabbit mAb | WB, IP, IF-F, IF-IC, F, ChIP | H, M, R |
| 51817S | ITK (E4X7M) Rabbit mAb (Biotinylated) | WB | H |
|
LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor® 488 Conjugate) |
IF-F, IF-IC |
M |
|
| 73294S | LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor® 594 Conjugate) | IF-F, IF-IC | M |
| 98215S | MSR1 (E7P6W) Rabbit mAb | IHC-P | M |
| 10054S | NEK7 Antibody | WB | H, M |
| 96874S | Phospho-NF-κB p65 (Ser529) Antibody | WB | H |
| 84223T | Human Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit | - | - |
| 97624T | Mouse Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit | - | - |
| PathScan® Phospho-Stat1 (Tyr701) Sandwich ELISA Kit | ELISA | H, M | |
| 73452S | Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) | F | H, M, R, Mk, (Hm, B, Pg, Hr) |
| 61958S | Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate) | F | H, M, R, Mk, (Hm, B, Pg, Hr) |
| 72337S | TNF-R2 (E8D7P) Rabbit mAb | WB, IP, F | H |
| 38519S | Toll-like Receptor 4 (E5D8T) Rabbit mAb | WB | H |
| 58125S | Tox (E5J8A) Rabbit mAb | IF-IC, F | H |
| 74698S | SARS-CoV-2 Envelope Protein Antibody | WB | Vir |
| 37393C | PathScan® SARS-CoV-2 Nucleocapsid Protein Sandwich ELISA Kit | ELISA | Vir |
| 34340S | SARS-CoV-2 ORF3a Antibody | WB, IP | Vir |
| MEK5 (E4C4B) Rabbit mAb | WB, IP | H, M, R | |
| AGK Antibody | WB | H | |
| 24972S | AIFM2/FSP1 Antibody | WB | H |
| 31219S | COX2/MT-CO2 Antibody | WB, IP | H, Mk |
| 26381S | DHODH (E9X8R) Rabbit mAb | WB | H, M, R |
| 17412S | MT-ATP8 Antibody | WB, IP | H |
| 45535S | Perilipin-2 Antibody | WB, IP | H |
| 65675S | TOM70 Antibody | WB | H, M, R |
| 53370S | Xanthine Dehydrogenase/Oxidase Antibody | WB | H |
|
PTMScan® HS Acetyl-Lysine Motif (Ac-K) Kit |
- |
- |
|
|
PathScan® β-Amyloid (1-40) Sandwich ELISA Kit |
ELISA |
H |
|
|
ApoE (E7X2A) Rabbit mAb |
WB, IP, IHC-P, IF-F, IF-IC |
M |
|
| 80718S | DNAJC7 Antibody | WB | H, M, R |
| 90963S | Neurexin-3 Antibody | WB | H, M, R |
|
α-Synuclein (E4U2F) XP® Rabbit mAb |
WB, IP, IHC-P, IF-F, IF-IC |
H, M, R |
|
|
TREM2-dependent mTOR Metabolic Fitness Antibody Sampler Kit |
- |
- |
|
| 96453S | Phospho-Axl (Tyr779) Antibody | WB, IP | H |
| 76799S | HER2/ErbB2 (CB11) Mouse mAb | IHC-Bond, IHC-P | H |
|
Translational Control |
|||
| 41025S | ADAR1 (E6X9R) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) | IF-IC, F | H, Mk |
| 31358S |
DIMT1 Antibody |
WB |
H, M, R, Mk |
|
Ubiquitin and Ubiquitin-like proteins |
|||
| 17579S | PSMB10/MECL-1 (E6R7O) Rabbit mAb | WB | H, M |
|
Related Products |
|||
| 20533S |
10% SDS Solution |
C&R |
- |
| 5708S | Anti-biotin (D5A7) Rabbit mAb (Alexa Fluor® 488 Conjugate) | F | All |
|
Glycine Solution (10X) |
ChIP, C&R |
- |
|
| 20664S | His-Tag (D3I1O) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) | IF-IC, F | All |
| 81940S | His-Tag (D3I1O) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate) | IF-IC, F | All |
| 67476S | V5-Tag (D3H8Q) Rabbit mAb (Sepharose® Bead Conjugate) | IP | All |
| 83862S | V5-Tag (E9H8O) Mouse mAb (Sepharose® Bead Conjugate) | IP | All |
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